The individuals represented in this collection are primarily members of the Theophilus A. Wylie family, immediate and extended. However, there are many hundreds of letters written to the family by friends far and wide. The bulk of the collection dates from 1850 through 1930, roughly the lifespan of Louisa Wylie Boisen, daughter of Theophilus A. and Rebecca D. Wylie, who was largely responsible for preserving the letters. The entire body of correspondence was part of the bequest to Wylie House Museum from Morton C. Bradley, Jr., great-grandson of Theophilus A. Wylie.